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Cefixime
- Pneumonia
- Acute bronchitis & acute exacerbations of chronic bronchitis
- Pharyngitis, tonsillitis
- Sinusitis, otitis media
- Typhoid fever
- Urinary tract infections
- Soft tissue infections
- Gonococcal urethritis
- Other susceptible bacterial infections
Cefixime works by binding to penicillin-binding proteins (PBPs), blocking the final step of bacterial cell wall synthesis. This disrupts peptidoglycan formation, weakens the bacterial cell wall, and leads to bacterial death.
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✅ Description:
Cefim-3 30ml contains Cefixime, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections. It is effective against infections of the respiratory tract (such as pneumonia, bronchitis, sinusitis), urinary tract, ear, throat, soft tissues, and certain sexually transmitted diseases (e.g., gonorrhea).
It may be taken with or without food, though taking it with meals or milk can help reduce stomach discomfort. To ensure the best results, take this medicine at evenly spaced intervals and at the same time each day. Complete the full prescribed course, even if you feel better before finishing, to prevent recurrence or antibiotic resistance.
- Complete the full prescribed course
- Take at the same time each day
- Report severe diarrhea, rash, or allergic reactions immediately
- Avoid alcohol to reduce the risk of side effects
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
Adults
- 200–400 mg daily, as a single dose or divided into two doses
- Gonorrhea: 400 mg as a single dose
- Typhoid fever: 20 mg/kg daily in 2 divided doses for 7–14 days
Children
- Above 6 months: 8 mg/kg/day in 1–2 divided doses
- 6 months–1 year: 75 mg daily
- 1–4 years: 100 mg daily
- 5–10 years: 200 mg daily
- >12 years or >50 kg: Adult dose
Typhoid fever: 15–20 mg/kg/day in 2 divided doses for 7–14 days (max 400 mg/day)
<6 months: Safety not established
Renal Impairment
If CrCl <20 mL/min → maximum dose: 200 mg/day
Administration
Can be taken with or without food
Best taken with food or milk to minimize stomach upset
✔️ Side Effects
- Nausea, abdominal pain, diarrhea, indigestion
- Headache, dizziness, flatulence, rash, pruritus, candidiasis
- Elevated liver enzymes, eosinophilia, leukopenia
- Pseudomembranous colitis (can be fatal)
- Stevens-Johnson syndrome
- Serum sickness-like reactions
- Thrombocytopenia
- Hypersensitivity reactions (rash, itching, facial swelling, breathing difficulty)
✔️ Interaction
Probenecid: Increases cefixime concentration
Anticoagulants: May increase prothrombin time → bleeding risk
Additive effects are possible with other nephrotoxic drugs
✔️ Contraindications
Hypersensitivity to cephalosporins
Use with caution in patients with a history of penicillin allergy
✔️
Pregnancy: Studies with cephalosporins, including cefixime, show no confirmed risk of major birth defects or miscarriage. However, use only if clearly needed.
Lactation: Drug presence in human milk not well studied; caution advised. Likely excreted in small amounts, as with other β-lactams.
✔️ Precautions
- History of penicillin allergy or hypersensitivity
- Renal impairment (dose adjustment required)
- Pregnancy & lactation (use only if prescribed)
- Gastrointestinal diseases, especially colitis
- Monitor for signs of superinfection with prolonged use
✔️ Storage:
Store in a cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
